Webb14 dec. 2024 · However, interestingly simvastatin prevented cardiac remodelling. Mechanistically, we found that simvastatin prevented uremic toxin-mediated M1 … Webb1 aug. 2024 · Simvastatin, a 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, has been shown to improve atherosclerosis (AS) via its anti …
Effect of simvastatin on MMPs and TIMPs in cigarette smoke …
Webb14 dec. 2024 · Mechanistically, we found that simvastatin prevented uremic toxin-mediated M1 polarisation in macrophage cells, thus preventing the production of FGF-23 from macrophage, suggesting that simvastatin improved UC phenotype through ameliorating inflammation phenotype in macrophage. WebbThere were also significant decreases in the average neointimal area in the simvastatin-treated group (21,669 ± 8636 µm 2 ) versus the control group (52,910 ± 21,738 µm 2 ; p < 0.05) and in ... rawis elementary school
Simvastatin attenuates macrophage-mediated gemcitabine …
WebbMacrophages treated with modified low-density lipoprotein express higher RIP140 mRNA and protein levels. Consistently, simvastatin reduces RIP140 levels, which can be reversed by mevalonate. Moreover, a high-fat diet elevates RIP140 but lowers miR-33 levels in peritoneal macrophages, and increases the production of IL-1β and TNF-α in … Webb7 apr. 2024 · PS-containing NPs are commonly used to mimic apoptotic cells and can specifically modulate macrophage function and enhance the targeting ability of macrophages [ 41 ], PS-modified nanostructured lipid carriers were further designed in some previous studies to improve hepatic delivery efficiency and its bioavailability, … WebbGTE effectively inhibits macrophage‐driven emphysematous lesions induced by CSC treatment, and these protective effects of GTE are closely related to the ERK/AP‐1 signaling pathway, followed by a reduced protease/antiprotease imbalance. Chronic obstructive pulmonary disease (COPD) is an important lung disease characterized by complicated … simple food diary printable