On target but off tumor
WebAffinity-tuning of CARs allows for detection of high-density target antigen on tumor cells while limiting reaction to low-density antigen on normal cells.7However, testing of on-target, off-tumor toxicity requires a mouse model that contains human antigen targets on both the tumor and in normal tissue. Web微信公众号抗体圈介绍：关注生物药行业动态，对热点进行深入解析。；赛诺菲：XPATs双抗，消除On-Target off tumor毒性
On target but off tumor
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Web非肿瘤靶向毒性（On-Target Off-Tumor） 非肿瘤靶向毒性，通常是因为靶点为共享靶点，在正常组织同样表达，会被CAR-T识别攻击，而引起的毒性。这一类毒副作用在CAR-T较 … Web15 de jul. de 2024 · Although a variety of CAR molecules have been developed so far, the clinical application for solid tumors is limited partly due to its adverse effect known as …
Web14 de jul. de 2024 · One of the major issues of CAR therapy in solid tumors is the selection of a target that maximizes anti-tumor activity while minimizing side effects (Flynn et al., … Web23 de jul. de 2024 · These findings highlight the importance of T cell targeting in reducing toxicity of normal tissue and also in preventing off-tumor sequestration of CARTs, which …
Web22 de mar. de 2024 · Chimeric antigen receptors (CARs) combine T cell activation with antibody-mediated tumor antigen specificity, bypassing the need for T cell receptor (TCR) ligation. A limitation of CAR technology is on-target off-tumor toxicity caused by target antigen expression on normal cells. Web12 de abr. de 2024 · Tumor-targeting specificity is the first and foremost determinant of both efficacy and safety in CAR-T cell therapy. The CAR molecules redirect T cell cytotoxicity toward target antigens...
Web12 de abr. de 2024 · However, some high-affinity TCRs have also proved to be fatal due to off-target immunotoxicity. This process occurs when the immune system acts against epitopes found on both tumor cells and healthy tissues. Moreover, some TCRs can be cross-reactive to epitopes with highly dissimilar sequences.
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