Ezrin overexpression
WebDec 2, 2024 · University of California San Diego, La Jolla, California, United States . Background: Human brain functions, including perception, attention, and other higher-order cognitive functions, are supported by neural oscillations necessary for the transmission of information across neural networks. Previous studies have demonstrated that the … WebFor example, overexpression of the phosphomimetic, constitutively active mutant T567D ezrin (but not of wild-type ezrin) in a murine T-lymphoma cell line and in naïve human T …
Ezrin overexpression
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WebJul 25, 2024 · The expression of Ezrin in colon adenocarcinoma tissues was screened by bioinformatics analysis and immunohistochemical assay. Si-RNA-mediated transfection and overexpression plasmid transfection were performed in colon adenocarcinoma cells. The proliferation viability was measured using MTT, colony formation, and EdU assays. WebEzrin is a membrane bound cytoskeleton linker protein which has been associated with poor outcome in a number of cancers [75,76]. High levels of ezrin expression have been shown to correlate with higher grade tumors, decreased disease-free survival rate in pediatric patients, and had a greater risk of metastatic relapse [77–80].
WebJun 22, 2024 · As already described, CHL1 overexpression in IMR-32 cell line provokes an opposite trend, but the co-silencing of ezrin reduces these effects, confirming the hypothesis that CHL1 acts in close ... WebFeb 1, 2024 · Both ezrin activation and overexpression are closely correlated with the progression of different types of cancers that are associated with MCI misregulation ( Table 1 ). For example, high expression of ezrin and phosphorylation of ezrin at tyrosine 353 are significantly associated with lymph node metastasis and poor prognosis in colorectal …
WebJun 23, 2010 · Establishment of ezrin overexpression monoclones and silencing of the ezrin gene in MiaPaCa-2 cells. To study the function of the Vil2 gene in MiaPaCa-2 cells, the pcb6-ezrin-VSV-G vector was adopted to stably overexpress the ezrin protein, and the pcb6 vector was used as a control. For ezrin silencing, the three ezrin siRNAs, … WebOverexpression of WAVE1 in K562 leukemia cells up-regulated P-gp and Ezrin, and reduced K562 cells' sensitivity to the chemotherapy drug adriamycin. The opposite effect was seen when WAVE1 expression was reduced via RNA interference. Critically, overexpression of WAVE1 in the absence of Ezrin did not affect P-gp levels or MDR. …
WebFeb 26, 2024 · An increasing amount of evidence indicate that Ezrin plays a central role in the development and progression of malignant tumours. …
WebJan 22, 2013 · Overexpression of B lymphoma Moloney murine leukemia virus insertion region-1 (BMI1), a transcription repressor that operates in stem cell maintenance and oncogenesis through inhibition of INK4A/ARF tumor suppressor locus, has been linked with increased incidence of metastasis in human gastric and breast cancer, as well as … mitchell harper dentist fort smithWebMay 1, 2004 · Therefore, rather than influencing only a single event, as do many other metastasis-associated molecules, ezrin overexpression might participate in many of the challenges that a proto-metastatic cell must overcome (Box 1). This suggests that ezrin and, by implication, other ERM proteins represent a crucial crossroad. Ezrin and cell-adhesion ... mitchell harley davidson modesto caWebJul 29, 2005 · The correlation between ezrin overexpression and the clinicopathological features of PDAC was evaluated using Chi-square test, and differences in survival curves were analyzed using log-rank tests. In results, ezrin protein is widely distributed in the cytoplasm and membrane of PDAC cells by IHC and IF staining, but some cases showed … mitchell harper x readerWebJan 9, 2024 · Here, we found that overexpression of phosphorylated ezrin resulted in increased cell migration. This is consistent with previous studies showing that the invasive and metastatic ability of cancer cells is linked to high expression of phosphorylated ezrin [20,21]. We propose that overexpression of phosphorylated ezrin is associated with a ... mitchell hardware storeWebOverexpression of ezrin appeared to promote a subtle change in moesin distribution, from a preferentially basolateral distribution (Fig. 9 D) to a more diffuse cytoplasmic staining … infrared physics \u0026 technology abbrWebFeb 12, 2024 · The overexpression of Ezrin promoted the migratory and invasive abilities of 22RV1 and PC-3 cells. Finally, the clinical data revealed that the expression of Ezrin in CTCs of PCa patients was significantly upregulated with the metastatic degree. mitchell harper limitedWebFeb 1, 2015 · The correlation between ezrin overexpression and the clinicopathological features of PDAC was evaluated using Chi-square test, and differences in survival … mitchell harrison hall