Dissection of autophagy in human platelets
WebDue to the unique properties of platelets, such as their lack of nuclei and their propensity for activation, methods for studying platelet autophagy must be specifically tailored. Here, … WebJan 1, 2024 · Europe PMC is an archive of life sciences journal literature.
Dissection of autophagy in human platelets
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WebSep 1, 2024 · Targeting autophagy-related signaling pathways to treat aortic aneurysm and dissection. 5.1. Targeting the mTOR signaling pathway. mTORC1 plays an important regulatory role in the initial stage of autophagy, and rapamycin, an inhibitor of mTOR, is a common inducer of autophagy [7]. Interestingly, mTOR signaling was increased in … WebApr 5, 2024 · Autophagy is constitutively and inductively present in stored platelets, and there exists a stable but slowly decayed autophagic flux during platelet storage, which …
WebRecently, we and others have shown that autophagy occurs in platelets and is important for platelet production and normal functions including hemostasis and thrombosis. Due to the unique properties of platelets, such as their lack of nuclei and their propensity for activation, methods for studying platelet autophagy must be specifically tailored. WebJan 5, 2024 · We and others [ 8, 9] have reported that as detected by immunoblotting, resting mouse and human platelets express numerous components of the major …
WebMar 8, 2024 · Feng W, Chang C, Luo D, Su H, Yu S, Hua W, Chen Z, Hu H, Liu W (2014) Dissection of autophagy in human platelets. Autophagy 10(4):642–651. Article CAS PubMed PubMed Central Google Scholar Ohto H, Nollet KE (2011) Overview on platelet preservation: better controls over storage lesion. Transfus Apher Sci 44(3):321–325 . … Webin developmental and pathological conditions, so far, the role of autophagy in platelet, a specific anucleate cell type, is poorly understood. in this study, we showed that human …
WebOct 25, 2024 · Using platelets isolated from septic patients and matched healthy controls, we show that during clinical sepsis, the number of autophagosomes is increased in platelets, most likely due to an...
WebMar 9, 2024 · Platelets are key players in hemostasis, the process that is essential in the prevention of blood loss in response to injury of a blood vessel. When platelets encounter breaches in the vascular wall, they rapidly adhere to the site of … geraldine knipe islington building controlWebThis was consistent with decreased fusion of autophagosomes with lysosomes in platelets. EPG5 (ectopic P-granules autophagy protein 5 homolog), a protein essential for normal autophagy, expression did increase, while protein-protein interactions between EPG5 and MAP1LC3/LC3 (which orchestrate the fusion of autophagosomes and lysosomes) were ... geraldine knoxWebIt is shown that human platelets express the autophagy-related proteins ATG5, ATG7, and LC3, and this results suggest a potential role of autophagic flux in the regulation of … christina brawner tiverton riWebContinuous turnover of intracellular components by autophagy is necessary to preserve cellular homeostasis in all tissues. Despite recent advances in identifying autophagy … christina brecht countersideWebUsing platelets isolated from septic patients and matched healthy controls, we show that during clinical sepsis, the number of autophagosomes is increased in platelets, most … geraldine kelly obituary columbus ohioWebSep 3, 2015 · Basal autophagy occurs in resting platelets. (A) Western blot analysis of LC3II in unstimulated human platelets treated with either NH 4 Cl (20 mM) or chloroquine … christinabrazilian jewelry designerWebIn this study, we showed that human platelets express the autophagy-related proteins ATG5, ATG7, and LC3. The same as in nucleated mammalian cells, autophagy was stimulated … geraldine king resource center